Medicinal plants play a crucial role in primary healthcare in numerous developing nations, primarily due to limited modern infrastructure, healthcare resources, traditional acceptance, pharmaceutical drug availability, and the effectiveness of these plants in addressing diseases that may not be effectively treated with modern therapies. This analysis delves into the phytochemistry, ethnomedical applications, pharmacological characteristics, and bioavailability of Berberis aquifolium, Curcuma longa, Echinacea angustifolia, and Thuja occidentalis, particularly in the context of treating dermatological issues. The research also investigates the potential of these compounds in the pharmaceutical industry, incorporating insights from clinical and toxicological studies. A comprehensive review of scientific literature led to the conclusion that these plants exhibit significant anticancer, anti-diabetic, anti-HIV, anti-inflammatory, analgesic, wound healing, and antimicrobial properties, making them safe for application on human skin.