The Genus Ficus, belonging to the family Moraceae, is well known for its medicinally important members. Particularly, the Indian Ficus tree is used in Ayurvedic medicine for many health conditions. Some Ficus species possess anticancer, immunostimulating, antidiabetic, antibacterial, antioxidant, antifungal, anti-arthritic, wound-healing, and neuroprotective properties. It has been discovered that different species of the Genus Ficus contain flavonoids, phenols, terpenoids, alkaloids, sugars, tannins, proteins, saponins, glycosides, volatile oils, and steroidal compounds. Indian Ficus has recently gained attention due to its high-value antioxidative property. The present review describes the phytochemistry, ethnomedicinal uses and pharmacological activities of different Indian Ficus species. The clinical and toxicological aspects for the exploration of their potential in the pharmaceutical sector are also included with recent developments in the field.