Medicinal plants have been in constant use since ancient times and are proven to be effective from time to time and even today, herbs are in great demand due to their high therapeutic values. The present paper highlights the usage of medicinal herbs against COVID-19 (SARS-CoV-2) which has brought on a global outbreak of severe respiratory disease. The Indian device of holistic medicine regarded as “Ayurveda” is playing a key role in controlling COVID-19 and its associated symptoms. Nutraceuticals and natural medicines can act as complementary preventive remedies for COVID-19. The literature survey presented several plant secondary metabolites that confirmed significant antiviral activity against SARS-CoV-2 through inhibiting the main proteins used in their pathogenesis and replication. This evaluation specializes in interpreting the capability of various secondary metabolites from medicinal herbs as healing alternatives, both as inhibitors of healing goals of SARS-CoV-2 or as blockers of viral debris access through host molecular receptors. The use of medicinal plants containing specific phytochemicals can be seen in offering a more secure and long-lasting answer for the population with lesser side effects. This review suggests certain Indian traditional medicinal plants as possible therapeutic targets exclusively against SARS-CoV-2.