Amlapitha (acid peptic disease) has a population prevalence of 6% and a male-female ratio of 1.7:1 in a study population of 10,096 urban dwellers. Two third of which constituted cases of duodenal ulcer and there has been a rapid rise in the 20th century globally. Amlapitha is a very common medical condition and the current management available for the same is not comprehensive. The aim of the present study is to assess the efficacy of guduchiyadi gana kwatha in the management of amlapitha. Ayurveda has a rich tradition in the management of gastroenterological disorders, but, due to reasons unknown, the full potential of Ayurvedic wisdom has not been explored so far in its management. Even the existing management is so trifled considering the plethora of management, principles and practice. So, it is highly essential that simple and cheap but effective formulation should be brought to the fore and the benefits of this great science to be extended to the suffering humanity. This would further help to popularize the system of Ayurveda. Existing treatment modalities available in Ayurveda for amlapitha are expensive, time-consuming and results unsatisfying. So, any initiative that would curtail the high cost and enhance the efficacy would be most welcomed. The existing kalpas used for amlapitha are composed of multiple drugs out of which some drugs are not available today. So, the simple formulation of guduchiyadi gana kwatha mentioned in Ashtanga Hrudaya would be highly practical considering the low cost and high availability of the drugs. Moreover, guduchiyadi gana is the best for the management of amlapitha.