The present study aimed to examine and compare the antidiabetic effect of different extracts of Epipremnum aureum on blood glucose levels, lipid profile, renal and hepatic function of streptozotocin (STZ)-induced diabetic rats. The animals showed a significant increase in the levels of blood glucose, total cholesterol, triglycerides, SGOT, SGPT, ALP, bilirubin, urea, uric acid, creatinine and total protein and a decrease in the HDL and antioxidant (SOD, GSH) levels when compared to the normal animals. The results demonstrated that ethanol extract showed more significant results as compared to acetone and chloroform extracts and also to standard preparation of Aloe vera.